منابع مشابه
Iconic feature based nonrigid registration: the PASHA algorithm
In this paper, we first propose a new subdivision of the image information axis used for the classification of nonrigid registration algorithms. Namely, we introduce the notion of iconic feature based (IFB) algorithms, which lie between geometrical and standard intensity based algorithms for they use both an intensity similarity measure and a geometrical distance. Then we present a new registra...
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Canonical primary microRNA (miRNA) transcripts and mirtrons are proposed to transit distinct nuclear pathways en route to generating mature approximately 22 nucleotide regulatory RNAs. We generated a null allele of Drosophila pasha, which encodes a double-stranded RNA-binding protein partner of the RNase III enzyme Drosha. Analysis of this mutant yielded stringent evidence that Pasha is essenti...
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Drosha is a type III RNase, which plays a critical role in miRNA biogenesis. Drosha and its double-stranded RNA-binding partner protein Pasha/DGCR8 likely recognize and cleave miRNA precursor RNAs or pri-miRNA hairpins cotranscriptionally. To identify RNAs processed by Drosha, we used tiling microarrays to examine transcripts after depletion of drosha mRNA with dsRNA in Drosophila Schneider S2 ...
متن کاملCharacterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing
DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) in eukaryotes. Although our knowledge of pri-miRNA processing has significantly advanced in recent years, the precise role of DGCR8 in this pathway remains unclear. In our present study, we dissect the domains in DGCR8 that con...
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Data mining has become one of the emerging fields in research because of its vast contents. Data mining is used for finding hidden patterns in the database or any other information repository. This information is necessary to generate knowledge from the patterns. The main task is to extract knowledge out of the information. In this paper we use a data mining technique called classification to d...
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ژورنال
عنوان ژورنال: The Geographical Journal
سال: 1914
ISSN: 0016-7398
DOI: 10.2307/1778383